The Wynne House was built in 1871 by Gustavius Adolphus Palm (1839-1917), a German-born architect who came to Holly Springs just before the Civil War and worked on many of the houses and churches in town. Palm is best known for his three great Italianate houses in Holly Springs: The Pines (1871) and Turner Lane House (1870), and this house, which Palm built for himself.
G. A. Palm sold his house in 1882 to William Lea, and eventually moved to Memphis. Lea owned the house until 1895, when it was sold to I. D. Blumenthal. The Blumenthal family lived here until 1906, when they sold it to L. A. Rather (1859-1930). In 1919 the house was purchased by Doctor Thomas C. Wynne, a dentist who lived here with his family until 1947. The Huggins family lived in the Wynne House from 1947 to 1973, and Reverend M. G. Schereff and his wife lived here from 1973 until 1999. Rosalind Wilcox owned the house for two years, before selling it to Irving Hall in 2001.
In 2008, Stephen and Jan Woodgate purchased the house and began a significant renovation of the Wynne House and the cottage next door, which the Woodgates called Hummingbird Cottage, and is today an excellent Bed and Breakfast whose proceeds go towards the continuing renovation and restoration of the Wynne House.
In 2016, the fully-restored Wynne House opened to the public as the Wynne House Inn.
The Wynne House is a two-story flanking-gable frame Italianate house, with gable-front ell, a tent-roof bay window and three-bay hip-roof porch. The house is noted for its heavy cornice brackets, the hallmark of the Italianate style.